As I rummaged through my fridge looking for dinner inspiration, I stumbled upon a treasure trove of ingredients just begging to be turned into something special—hence, the creation of my High-Protein Spinach and Artichoke Chicken Casserole! This comforting dish perfectly combines the rich flavors of creamy artichoke and vibrant spinach with hearty shredded chicken, creating a meal that’s both satisfying and nourishing. With the hustle of weeknight dinners, this simple preparation offers a delightful escape from takeout, making it perfect for busy families or a cozy weekend gathering. Plus, it’s not just delicious; it’s also packed with protein and gluten-free-friendly options that everyone can enjoy. Intrigued? Let’s dive into this delicious recipe that’s sure to become a staple in your home!

Why is this casserole a must-try?
Comforting Flavor: Your taste buds will be delighted by the rich, creamy blend of artichokes and spinach combined with tender chicken.
High-Protein Goodness: Packed with approximately 45g of protein per serving, this dish is perfect for health-conscious food lovers.
Quick Preparation: From mixing to baking, you can whip this up in under an hour, making it ideal for busy weeknights.
Versatile Ingredients: Easily customize with leftover chicken or swap spinach for kale, ensuring it always fits your fridge’s contents.
Crowd-Pleasing Satisfaction: It’s a dish that brings everyone together, whether at a family dinner or as part of a potluck spread—perfect alongside a refreshing green salad!
Spinach and Artichoke Chicken Casserole Ingredients
For the Casserole
• Chicken Breasts – Cooked and shredded chicken provides the primary protein source; substitute with leftover rotisserie chicken for quicker prep.
• Fresh Baby Spinach – Adds nutritional value and vibrant green color; you can substitute with kale, but texture may differ.
• Artichoke Hearts – Contributes unique flavor and texture; use canned, frozen, or fresh artichokes, ensuring they are drained well.
• Non-Fat Greek Yogurt – Acts as a creamy base while boosting protein content; replace with sour cream for a tangy twist if desired.
• Light Cream Cheese – Provides creaminess and richness; opt for full-fat cream cheese for a richer flavor.
• Shredded Mozzarella Cheese – Melts beautifully for a cheesy top layer; try provolone or cheddar for varied flavor combinations.
• Grated Parmesan Cheese – Enhances flavor with a salty, nutty taste; nutritional yeast can be used for a dairy-free option.
• Garlic – Adds an aromatic flavor; garlic powder may be used in a pinch.
• Salt & Black Pepper – Essential seasonings to enhance flavors in this Spinach and Artichoke Chicken Casserole.
Optional Topping
• Chopped Fresh Herbs – Fresh parsley or thyme elevate the dish’s flavor; sprinkle on before serving for an added touch.
Step‑by‑Step Instructions for Spinach and Artichoke Chicken Casserole
Step 1: Preheat the Oven
Start by preheating your oven to 375°F (190°C). Meanwhile, grab a medium-sized casserole dish and grease it lightly with cooking spray or a touch of oil. This will help prevent sticking and ensure that your delicious spinach and artichoke chicken casserole bakes evenly without any fuss when serving.
Step 2: Prepare the Creamy Base
In a large mixing bowl, combine non-fat Greek yogurt, light cream cheese, minced garlic, salt, and black pepper. Using a hand mixer or a sturdy spatula, whip everything together until you achieve a smooth and creamy texture. This base will form the delicious heart of your casserole, so take a moment to ensure it’s perfectly blended.
Step 3: Mix in the Main Ingredients
Next, fold in the shredded chicken, fresh baby spinach, and artichoke hearts to the creamy mixture. Gently stir with your spatula until everything is thoroughly combined and coated. The vibrant green spinach should be distributed evenly throughout, bringing color and nutrition to your spinach and artichoke chicken casserole.
Step 4: Transfer to Casserole Dish
Carefully transfer the mixture into your greased casserole dish. Make sure to spread it out evenly with the spatula for consistent cooking. Once smooth and level, sprinkle half of the shredded mozzarella cheese on top, allowing it to melt beautifully during baking and adding that gooey goodness we all love.
Step 5: Add Final Toppings
Now, it’s time to top off your casserole! Sprinkle the remaining mozzarella cheese over the entire surface, followed by a generous coating of grated Parmesan cheese. This adds a lovely flavor dimension and an appealing golden-brown crust as it bakes—a hallmark of a successful spinach and artichoke chicken casserole.
Step 6: Bake Until Golden and Bubbly
Place the assembled casserole in your preheated oven and let it bake for about 30-35 minutes. Keep an eye on it; you’re looking for a bubbly texture and a beautifully golden-brown top. This visual cue indicates that your dish is perfectly done and ready to bring comfort to your family’s dinner table.
Step 7: Cool Before Serving
Once baked, remove your spinach and artichoke chicken casserole from the oven and allow it to cool for about 5 minutes. This brief resting period will help the casserole set a little, making it easier to portion and serve. The delightful aromas will fill your kitchen, enticing everyone to the meal ahead!

Make Ahead Options
These Spinach and Artichoke Chicken Casserole is perfect for meal prep enthusiasts! You can prepare the creamy filling up to 24 hours in advance by mixing the Greek yogurt, cream cheese, garlic, salt, and pepper, then folding in the shredded chicken, spinach, and artichokes. Store the mixture in an airtight container in the refrigerator to maintain its quality. Just before baking, transfer it to your greased casserole dish, sprinkle with mozzarella and Parmesan, then pop it in the oven. Bake at 375°F (190°C) for 30-35 minutes until bubbly and golden. This simple prep not only saves you time but ensures a delicious meal awaits with minimal effort on busy nights!
What to Serve with High-Protein Spinach and Artichoke Chicken Casserole
Complement this creamy casserole with delightful sides that enhance its comforting flavors and make for a satisfying meal.
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Crusty Bread: Perfect for soaking up every cheesy bite, fresh crusty bread provides a satisfying crunch and warmth. It’s a delightful contrast to the creamy casserole.
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Green Salad: A light, crisp green salad is an excellent choice to balance the richness of the casserole. Toss in some cherry tomatoes and avocado for freshness and color.
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Roasted Vegetables: Add a pop of color and nutrition by serving roasted vegetables like carrots and bell peppers. Their sweetness will beautifully complement the savory chicken casserole.
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Garlic Breadsticks: The buttery, garlicky flavor of breadsticks adds an indulgent touch, creating a hearty meal everyone will love. Pair with your favorite marinara for dipping!
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Quinoa Pilaf: A protein-packed quinoa pilaf offers a nutty flavor and a perfect texture to contrast the creamy casserole. Garnish with fresh herbs for added brightness.
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Stuffed Mushrooms: Bite-sized stuffed mushrooms offer an elegant and delicious side. Keeps with the comfort food vibe while adding indulgent herbs and cheeses.
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White Wine: A chilled glass of white wine, like a crisp Sauvignon Blanc, complements the flavors of spinach and artichoke beautifully, making for a refreshing sip with each bite.
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Fruit Sorbet: For dessert, a refreshing fruit sorbet will cleanse the palate after your hearty casserole, leaving everyone satisfied yet light. Choose flavors like lemon or raspberry for a zesty finish.
Spinach and Artichoke Chicken Casserole Variations
Feel free to get creative with this recipe and tailor it to your tastes for a delightful twist on an already comforting dish!
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Kale Swap: Replace spinach with kale for a heartier version. It offers a different texture and nutritious benefits.
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Veggie Boost: Add bell peppers or mushrooms to enhance both the flavor and nutrition in your casserole. Experiment with your favorite vegetables!
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Spicy Kick: Incorporate red pepper flakes or diced jalapeños for a heated twist that elevates the flavor profile splendidly. Just a hint of heat can make all the difference!
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Dairy-Free Delight: Use cashew cream or a coconut-based yogurt in place of Greek yogurt for a creamy, non-dairy alternative. This can make a hearty dish accessible for those avoiding dairy.
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Full-Fat Flavor: Swap in full-fat cream cheese for a richer texture and flavor; it will take the creaminess to another level.
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Cheddar Twist: Blend in shredded cheddar cheese with the mozzarella for a sharp, tangy flavor contrast. This cheese combo is both delicious and indulgent.
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Lentil Addition: If you’re feeling adventurous, mix in cooked lentils for an extra protein punch and a satisfying texture, making the dish even more filling.
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Fresh Herb Medley: Add fresh herbs like basil or thyme to the mixture before baking for an aromatic layer that complements the classic flavors beautifully.
If you’re looking for more inventive recipes, you can explore options like Chicken Sausage Broccoli or try out these delightful Cheesy Buffalo Chicken delights for more inspiration!
Expert Tips for Spinach and Artichoke Chicken Casserole
- Avoid Overbaking: Keep an eye on your casserole; overbaking can dry it out. You want a golden top with melted cheese that’s still moist.
- Prep Ahead: If possible, assemble the casserole the night before and refrigerate it. This saves time when you’re ready to bake and allows flavors to meld.
- Use Fresh Ingredients: Fresh baby spinach and artichokes elevate your spinach and artichoke chicken casserole to another level of flavor; if using frozen, ensure they are well-drained.
- Customize Flavor: Don’t hesitate to add spices like garlic powder or red pepper flakes for extra depth; a pinch can transform the dish!
- Meal Prep Friendly: This casserole stores well in the fridge and makes great leftovers. Enjoy up to three days later, simply reheat in the microwave or oven.
How to Store and Freeze Spinach and Artichoke Chicken Casserole
Fridge: Store leftover spinach and artichoke chicken casserole in an airtight container for up to 3 days. Reheat in the microwave or oven until warmed through.
Freezer: For longer storage, freeze the assembled casserole (before baking) in a tightly sealed container for up to 3 months. Thaw overnight in the fridge before baking.
Reheating: Reheat individual portions in the microwave for quick meals, or bake in the oven at 350°F (175°C) until heated through.
Covering: Always cover tightly with foil or a lid to prevent moisture loss and keep the casserole fresh.

Spinach and Artichoke Chicken Casserole Recipe FAQs
What type of spinach should I use for the casserole?
Absolutely! Fresh baby spinach is ideal for this recipe as it adds both nutritional value and a vibrant green color. If fresh isn’t available, you can use frozen spinach; just ensure it’s fully thawed and well-drained to avoid excess moisture in your casserole.
How do I store leftover casserole?
You can store leftover spinach and artichoke chicken casserole in an airtight container in the fridge for up to 3 days. I recommend covering it tightly to maintain its moisture and flavor. When you’re ready to enjoy it again, simply reheat portions in the microwave or oven until warmed through.
Can I freeze the spinach and artichoke chicken casserole?
Yes! You can freeze the assembled casserole (before baking) in a tightly sealed container or freezer-safe dish. It will keep well in the freezer for up to 3 months. To use, thaw it overnight in the fridge and then bake according to the original instructions. Just bear in mind that the texture may change slightly after thawing.
What should I do if my casserole is too dry?
Very! If you find your spinach and artichoke chicken casserole ends up too dry, consider before serving to drizzle a little chicken broth or cream over the top and give it a gentle stir. This can help restore moisture without compromising flavors. Additionally, you might try covering the casserole with foil for part of the baking time to trap steam.
Are there any dietary considerations with this dish?
Definitely! This recipe is quite versatile, making it easy to modify for various dietary needs. For a dairy-free option, you can replace the cream cheese and Greek yogurt with plant-based alternatives. Also, be sure to check your canned artichokes and cream cheese for any potential allergens like soy or nut derivatives if you’re serving guests with food allergies.

Spinach and Artichoke Chicken Casserole: A Creamy Delight!
Ingredients
Equipment
Method
- Preheat your oven to 375°F (190°C) and lightly grease a medium casserole dish.
- In a large mixing bowl, combine Greek yogurt, cream cheese, minced garlic, salt, and black pepper, and whip until smooth.
- Fold in shredded chicken, spinach, and artichoke hearts until evenly coated.
- Transfer the mixture into the greased casserole dish and spread evenly.
- Sprinkle half of the mozzarella cheese on top.
- Top with the remaining mozzarella cheese and grated Parmesan cheese.
- Bake for about 30-35 minutes until bubbly and golden-brown.
- Allow to cool for about 5 minutes before serving.

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